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Image Search Results
Journal: PLoS Genetics
Article Title: A Mutation in the Gene Encoding Mitochondrial Mg 2+ Channel MRS2 Results in Demyelination in the Rat
doi: 10.1371/journal.pgen.1001262
Figure Lengend Snippet: Immunohistochemistry for Iba1 in the lumbar part of the spinal cord of wild-type (A) and Mrs2 dmy /Mrs2 dmy rats (B) at 6 weeks of age. Signals of Iba1 (AlexaFluor 546 nm; red), which is upregulated during the activation of microglia, are seen in Mrs2 dmy /Mrs2 dmy rats much more the wild-type control. Nucleus is stained with DAPI (blue). C, Inflammatory cytokine mRNA expression in the CNS of wild-type (□) and Mrs2 dmy /Mrs2 dmy (▪) rats. IL1b expression was elevated in Mrs2 dmy /Mrs2 dmy rats at 4 and 6 weeks of age. IL6 was elevated in Mrs2 dmy /Mrs2 dmy rats at 6 weeks of age. * P<0.05, ** P<0.005.
Article Snippet:
Techniques: Immunohistochemistry, Activation Assay, Control, Staining, Expressing